11. C[BOND]H Activation of Heteroaromatics

  1. Peter J. Dunn2,
  2. K. K. (Mimi) Hii3,
  3. Michael J. Krische4 and
  4. Michael T. Williams5
  1. Koji Hirano and
  2. Masahiro Miura

Published Online: 23 MAY 2013

DOI: 10.1002/9781118354520.ch11

Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries

Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries

How to Cite

Hirano, K. and Miura, M. (2013) C[BOND]H Activation of Heteroaromatics, in Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries (eds P. J. Dunn, K. K. (. Hii, M. J. Krische and M. T. Williams), John Wiley & Sons, Inc., Hoboken, New Jersey. doi: 10.1002/9781118354520.ch11

Editor Information

  1. 2

    Pfizer Green Chemistry Lead, Sandwich, Kent, United Kingdom

  2. 3

    Imperial College London, South Kensington, London, United Kingdom

  3. 4

    University of Texas at Austin, Austin, Texas, United States of America

  4. 5

    CMC Consultant, Deal, Kent, United Kingdom

Author Information

  1. Division of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Osaka, Japan

Publication History

  1. Published Online: 23 MAY 2013
  2. Published Print: 8 APR 2013

ISBN Information

Print ISBN: 9781118155424

Online ISBN: 9781118354520

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Keywords:

  • alkenylation;
  • alkylation;
  • alkynylation;
  • arylation;
  • C[BOND]H activation;
  • heteroaromatics

Summary

The metal-mediated C[BOND]H activation has recently received significant attention in modern organic synthesis because it can obviate at least one of the preactivation steps (halogenation or stoichiometric metalation) of starting materials necessary for the application of “classical” cross-coupling methodologies. This chapter focuses on the recent advances in the metal-mediated C[BOND]C bond formation on biologically and physically interesting heteroaromatics via C[BOND]H bond cleavage: direct arylation, alkenylation, alkynylation, and alkylation