13. Innate Immunity in Atherosclerosis

  1. Gary S. Hoffman MD, MS3,
  2. Cornelia M. Weyand MD, PhD4,
  3. Carol A. Langford MD, MHS3 and
  4. Jörg J. Goronzy MD, PhD4
  1. Shuang Chen MD, PhD1,
  2. Prediman K. Shah MD2 and
  3. Moshe Arditi MD1

Published Online: 3 MAY 2012

DOI: 10.1002/9781118355244.ch13

Inflammatory Diseases of Blood Vessels, Second Edition

Inflammatory Diseases of Blood Vessels, Second Edition

How to Cite

Chen, S., Shah, P. K. and Arditi, M. (2012) Innate Immunity in Atherosclerosis, in Inflammatory Diseases of Blood Vessels, Second Edition (eds G. S. Hoffman, C. M. Weyand, C. A. Langford and J. J. Goronzy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118355244.ch13

Editor Information

  1. 3

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

  2. 4

    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Author Information

  1. 1

    Division of Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

  2. 2

    Division of Cardiology/Heart Institute, Oppenheimer Atherosclerosis Research Center, Burns and Allen Research Institute, Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

Publication History

  1. Published Online: 3 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9781444338225

Online ISBN: 9781118355244



  • Atherosclerosis;
  • Toll-like receptor;
  • innate immunity;
  • inflammation


Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence suggests that innate immune defense mechanisms might interact with pro-inflammatory pathways and exacerbate or perhaps even initiate development of arterial plaques. Recent data directly implicates signaling by Toll-like receptors (TLR), especially TLR4 and TLR2 in the pathogenesis of atherosclerosis, establishing a key link between atherosclerosis and defense against both foreign pathogens and endogenously generated inflammatory ligands. There are intriguing suggestions that innate immunity may participate in several other clinically important vascular pathologies as well such as post-injury neointimal thickening responsible for post-angioplasty and post-stent restenosis. Here we briefly review these and closely related studies, highlighting areas that should provide fertile ground for future studies aimed at a more comprehensive understanding of the interplay between innate immune defense mechanisms, atherosclerosis and related vascular disorders.