16. Approach to the Differential Diagnosis of Vasculitis

  1. Gary S. Hoffman MD, MS2,
  2. Cornelia M. Weyand MD, PhD3,
  3. Carol A. Langford MD, MHS2 and
  4. Jörg J. Goronzy MD, PhD3
  1. Eamonn S. Molloy MD, MS, MRCPI1 and
  2. Carol A. Langford MD, MHS2

Published Online: 3 MAY 2012

DOI: 10.1002/9781118355244.ch16

Inflammatory Diseases of Blood Vessels, Second Edition

Inflammatory Diseases of Blood Vessels, Second Edition

How to Cite

Molloy, E. S. and Langford, C. A. (2012) Approach to the Differential Diagnosis of Vasculitis, in Inflammatory Diseases of Blood Vessels, Second Edition (eds G. S. Hoffman, C. M. Weyand, C. A. Langford and J. J. Goronzy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118355244.ch16

Editor Information

  1. 2

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

  2. 3

    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Author Information

  1. 1

    Department of Rheumatology, St Vincent's University Hospital, Dublin, Ireland

  2. 2

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

Publication History

  1. Published Online: 3 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9781444338225

Online ISBN: 9781118355244

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Keywords:

  • Primary systemic vasculitis;
  • secondary vasculitis;
  • vasculitis mimics;
  • aortitis;
  • temporal arteritis;
  • medium vessel vasculitis;
  • pulmonary–renal syndrome;
  • rhinosinusitis;
  • cutaneous vasculitis;
  • cerebral vasculitis

Summary

The diagnosis of primary systemic vasculitis should be considered in any patient presenting with multisystem disease. However, vasculitis may arise secondary to infectious processes, drugs/toxins, malignancy or systemic autoimmune diseases. Furthermore, many disorders, including genetic, congenital, neoplastic and degenerative diseases, may mimic the clinical and radiologic features of the primary vasculitides. Therefore, the diagnosis of primary systemic vasculitis requires careful assessment of all available clinical, laboratory, radiologic and pathologic information, and consideration of many competing differential diagnoses. Exclusion of secondary forms of vasculitis and noninflammatory mimics of vasculitis is essential to avoid unnecessary and potentially harmful treatment with immunosuppressive agents.