3. Leukocyte Trafficking

  1. Gary S. Hoffman MD, MS2,
  2. Cornelia M. Weyand MD, PhD3,
  3. Carol A. Langford MD, MHS2 and
  4. Jörg J. Goronzy MD, PhD3
  1. Braedon McDonald BSc(Hon) and
  2. Paul Kubes PhD

Published Online: 3 MAY 2012

DOI: 10.1002/9781118355244.ch3

Inflammatory Diseases of Blood Vessels, Second Edition

Inflammatory Diseases of Blood Vessels, Second Edition

How to Cite

McDonald, B. and Kubes, P. (2012) Leukocyte Trafficking, in Inflammatory Diseases of Blood Vessels, Second Edition (eds G. S. Hoffman, C. M. Weyand, C. A. Langford and J. J. Goronzy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118355244.ch3

Editor Information

  1. 2

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

  2. 3

    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Author Information

  1. Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Health Research Innovation Center, Calgary, Canada

Publication History

  1. Published Online: 3 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9781444338225

Online ISBN: 9781118355244



  • Cell trafficking;
  • recruitment;
  • leukocytes;
  • endothelium;
  • microcirculation;
  • selectins;
  • integrins;
  • chemoattractants


Immunologic functions depend on the ability of leukocytes to migrate to tissues throughout the body. Trafficking of leukocytes from the bloodstream into tissues involves a cascade of molecularly distinct interactions with the vascular endothelium. This chapter discusses the mechanisms that control leukocyte trafficking and the potential therapeutic benefits of targeting cell migration to treat inflammatory pathologies.