34. Drug-Induced Vasculitis

  1. Gary S. Hoffman MD, MS2,
  2. Cornelia M. Weyand MD, PhD3,
  3. Carol A. Langford MD, MHS2 and
  4. Jörg J. Goronzy MD, PhD3
  1. Peter A. Merkel MD, MPH

Published Online: 3 MAY 2012

DOI: 10.1002/9781118355244.ch34

Inflammatory Diseases of Blood Vessels, Second Edition

Inflammatory Diseases of Blood Vessels, Second Edition

How to Cite

Merkel, P. A. (2012) Drug-Induced Vasculitis, in Inflammatory Diseases of Blood Vessels, Second Edition (eds G. S. Hoffman, C. M. Weyand, C. A. Langford and J. J. Goronzy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118355244.ch34

Editor Information

  1. 2

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

  2. 3

    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Author Information

  1. University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Publication History

  1. Published Online: 3 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9781444338225

Online ISBN: 9781118355244

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Keywords:

  • Vasculitis;
  • drug;
  • medication;
  • ANCA;
  • causality;
  • treatment;
  • pathology;
  • diagnosis

Summary

Drug-induced vasculitis is defined as any type of inflammatory vascular disorder caused by the administration of a pharmacologic agent. The clinical presentation of drug-induced vasculitis ranges from isolated skin or central nervous system disease to multiorgan involvement. Drugs from almost every pharmaceutical class and category have been cited as causal agents for drug-induced vasculitis, including antimicrobials, immunosuppressive and chemotherapeutic agents, drugs of abuse, psychotropic medications and many others. The level of evidence establishing causality of specific agents with vasculitis varies greatly. Treatment of drug-induced vasculitis includes the withdrawal of the putative causative agent and consideration, in selected cases, of the use of glucocorticoids and/or immunosuppressive drugs. This chapter reviews the approach to diagnosis, causative agents, clinical features, laboratory findings, histopathology and treatment of drug-induced vasculitis.