4. Dendritic Cells and Vascular Inflammation

  1. Gary S. Hoffman MD, MS1,
  2. Cornelia M. Weyand MD, PhD2,
  3. Carol A. Langford MD, MHS1 and
  4. Jörg J. Goronzy MD, PhD2
  1. Cornelia M. Weyand MD, PhD

Published Online: 3 MAY 2012

DOI: 10.1002/9781118355244.ch4

Inflammatory Diseases of Blood Vessels, Second Edition

Inflammatory Diseases of Blood Vessels, Second Edition

How to Cite

Weyand, C. M. (2012) Dendritic Cells and Vascular Inflammation, in Inflammatory Diseases of Blood Vessels, Second Edition (eds G. S. Hoffman, C. M. Weyand, C. A. Langford and J. J. Goronzy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118355244.ch4

Editor Information

  1. 1

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

  2. 2

    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Author Information

  1. Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Publication History

  1. Published Online: 3 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9781444338225

Online ISBN: 9781118355244

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Keywords:

  • Vascular dendritic cells;
  • PAMP;
  • DAMP

Summary

Blood vessels secure oxygen and nutrient supply to tissues and maintain perfusion by regulating blood pressure. Medium and large human arteries with three wall layers and vasa vasorum have another pivotal biologic function. Through immune sentinels, vascular dendritic cells (vasDC) that are embedded into the wall-layers, such arteries participate in immunosurveillance. VasDC recognize pathogen-associated and danger-associated molecular patterns (PAMPs and DAMPs, respectively) and interact with the adaptive immune system. Comparative genomics have established that arteries from different vascular beds (aorta, carotid, subclavian, temporal, mesenteric, and iliac) express a vessel-specific profile of pattern recognition receptors and have an immunologic identity. VasDC are critically involved in initiating vessel wall inflammation and remain indispensable antigen-presenting cells in established vasculitis where they activate multiple T-cell effector lineages and shape the microarchitecture of the inflammatory infiltrates. By virtue of their pinnacle role in large vessel vasculitis, vasDC emerge as ideal therapeutic targets for immunomodulatory interventions.