6. Autoantibodies and Vascular Inflammation

  1. Gary S. Hoffman MD, MS4,
  2. Cornelia M. Weyand MD, PhD5,
  3. Carol A. Langford MD, MHS4 and
  4. Jörg J. Goronzy MD, PhD5
  1. Abraham Rutgers MD, PhD1,
  2. Jan S. F. Sanders MD, PhD2,
  3. Jan Willem Cohen Tervaert MD, PhD3 and
  4. Cees G. M. Kallenberg MD, PhD1

Published Online: 3 MAY 2012

DOI: 10.1002/9781118355244.ch6

Inflammatory Diseases of Blood Vessels, Second Edition

Inflammatory Diseases of Blood Vessels, Second Edition

How to Cite

Rutgers, A., Sanders, J. S. F., Cohen Tervaert, J. W. and Kallenberg, C. G. M. (2012) Autoantibodies and Vascular Inflammation, in Inflammatory Diseases of Blood Vessels, Second Edition (eds G. S. Hoffman, C. M. Weyand, C. A. Langford and J. J. Goronzy), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118355244.ch6

Editor Information

  1. 4

    Department of Rheumatic and Immunologic Diseases, Center for Vasculitis Care and Research, Cleveland Clinic, Lerner College of Medicine, Cleveland, OH, USA

  2. 5

    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

Author Information

  1. 1

    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

  2. 2

    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

  3. 3

    Division of Clinical and Experimental Immunology, Department of Internal Medicine, Maastricht University Medical Center, The Netherlands

Publication History

  1. Published Online: 3 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9781444338225

Online ISBN: 9781118355244

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Keywords:

  • ANCA;
  • MPO-ANCA;
  • PR3-ANCA;
  • AECA;
  • anti-cPR3;
  • anti-LAMP2;
  • vasculitis;
  • autoantibodies

Summary

The primary vasculitides are autoimmune diseases often characterized by the presence of autoantibodies. These antibodies can help in correctly diagnosing patients (e.g. antineutrophil cytoplasmic antibody [ANCA] associated vasculitis) and in monitoring patients during follow-up. Also, they provide insight in the underlying pathogenic processes and therefore may be instrumental in developing improved treatment options. This chapter describes current knowledge on the presence of autoantibodies in different vasculitic diseases with a focus on PR3-ANCA, MPO-ANCA, anticomplementary proteinase 3 (anti-cPR3) antibodies, antilysosomal membrane protein-2 (LAMP-2) antibodies and antiendothelial antibodies (AECA). Furthermore, we discuss the pathogenic potential of these autoantibodies and their (potential) therapeutic implications.