3. The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife

  1. Peter Matthiessen
  1. Hans-Christian Stolzenberg1,
  2. Tobias Frische1,
  3. Vicki L. Dellarco2,
  4. Gary Timm2,
  5. Anne Gourmelon3,
  6. Taisen Iguchi4,
  7. Flemming Ingerslev5 and
  8. Mike Roberts6

Published Online: 22 MAR 2013

DOI: 10.1002/9781118355961.ch3

Endocrine Disrupters: Hazard Testing and Assessment Methods

Endocrine Disrupters: Hazard Testing and Assessment Methods

How to Cite

Stolzenberg, H.-C., Frische, T., Dellarco, V. L., Timm, G., Gourmelon, A., Iguchi, T., Ingerslev, F. and Roberts, M. (2013) The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards to Wildlife, in Endocrine Disrupters: Hazard Testing and Assessment Methods (ed P. Matthiessen), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118355961.ch3

Editor Information

  1. Consultant Ecotoxicologist

Author Information

  1. 1

    Federal Environment Agency (Umweltbundesamt), Dessau-Rosslau, Germany

  2. 2

    United States Environment Protection Agency (USEPA), Washington, DC, United States

  3. 3

    Organization for Economic Co-operation and Development (OECD), Paris, France

  4. 4

    Department of Bioenvironmental Research, Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, Okazaki, Japan

  5. 5

    Danish Environmental Protection Agency, Copenhagen, Denmark

  6. 6

    Department for Environment, Food and Rural Affairs, London, United Kingdom

Publication History

  1. Published Online: 22 MAR 2013
  2. Published Print: 8 MAR 2013

ISBN Information

Print ISBN: 9780470932094

Online ISBN: 9781118355961



  • Endocrine Disruptor Screening Program;
  • endocrine-active substances;
  • endocrine-disrupting chemicals (EDCs);
  • hazard characterization;
  • regulatory frameworks;
  • Tier 1 testing;
  • wildlife


This chapter describes how regulatory authorities tackle a prevalent predicament that also applies to the issue of endocrine-disrupting chemicals (EDCs). It describes the regulatory challenge bridging between a general concern, driven not only by science but also by policy, and the need to respond in various specific regulatory frameworks. With brief analyses of the major substance-related European regulatory frameworks, the chapter examines how EDCs are being addressed and what the most recent developments are. The chapter illustrates by several examples that the challenge to develop and agree adequate and operational definitions and specific scientific decision criteria for EDCs still has to be tackled in substance-related regulatory frameworks. The description and analysis provided by this chapter show that quite a few issues need further regulatory consideration, from the viewpoints of scientific hazard and risk assessment, risk management, and policy development.