7. USE OF TRANSITION METAL–CATALYZED CASCADE REACTIONS IN NATURAL PRODUCT SYNTHESIS AND DRUG DISCOVERY

  1. Peng-Fei Xu1 and
  2. Wei Wang2
  1. Peng-Fei Xu and
  2. Hao Wei

Published Online: 18 OCT 2013

DOI: 10.1002/9781118356654.ch7

Catalytic Cascade Reactions

Catalytic Cascade Reactions

How to Cite

Xu, P.-F. and Wei, H. (2013) USE OF TRANSITION METAL–CATALYZED CASCADE REACTIONS IN NATURAL PRODUCT SYNTHESIS AND DRUG DISCOVERY, in Catalytic Cascade Reactions (eds P.-F. Xu and W. Wang), John Wiley & Sons, Inc, Hoboken, NJ. doi: 10.1002/9781118356654.ch7

Editor Information

  1. 1

    State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P.R. China

  2. 2

    Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico

Publication History

  1. Published Online: 18 OCT 2013
  2. Published Print: 24 OCT 2013

ISBN Information

Print ISBN: 9781118016022

Online ISBN: 9781118356654

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Keywords:

  • cascade reactions;
  • cross-coupling reactions;
  • Heck reaction;
  • natural product synthesis;
  • stille reaction;
  • suzuki coupling reaction;
  • transition metal;
  • Tsuji–Trost reaction

Summary

Transition metal–catalyzed domino reactions are of special interest in the preparation of natural products and analogs as important lead structures in the development of bioactive compounds. Moreover, they can be used for the synthesis of any other types of compound as well as being used in combinatorial chemistry. Recently, a number of excellent transition metal–catalyzed cascades were developed and reported which have attracted significant attention for synthetic chemists, due to their high efficiency and diversity. Using well-designed strategies, transition metal–catalyzed cascades have been used successfully in the total synthesis of some natural products. In the twentieth century, palladium was the most important metal catalyst in transition metal–catalyzed organic transformations. Many types of transformations can be catalyzed by a palladium catalyst, including the Heck reaction, the cross-coupling reaction, and the Tsuji–Trost reaction.