4. Glycine, Serine and the One-Carbon Pool

  1. David A Bender

Published Online: 2 JUL 2012

DOI: 10.1002/9781118357514.ch4

Amino Acid Metabolism, Third Edition

Amino Acid Metabolism, Third Edition

How to Cite

Bender, D. A. (2012) Glycine, Serine and the One-Carbon Pool, in Amino Acid Metabolism, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118357514.ch4

Author Information

  1. University College, London, UK

Publication History

  1. Published Online: 2 JUL 2012
  2. Published Print: 10 AUG 2012

ISBN Information

Print ISBN: 9780470661512

Online ISBN: 9781118357514



  • glycine, serine and the one-carbon pool;
  • glycine role in protein synthesis, creatine synthesis precursor;
  • metabolic sources of glycine;
  • glycine and serine, and serine as precursor in gluconeogenesis;
  • hydroxymethyltransferase, pyridoxal phosphate-dependent aldolase;
  • glycine cleavage, mitochondrial multi-enzyme and oxidative decarboxylation;
  • non-ketotic hyperglycinaemia, and glycine cleavage system defect;
  • glycine and serine, one-carbon units for biosynthetic reactions;
  • serine catabolism, metabolic fate of serine;
  • selenocysteine termination/insertion, next base after UGA codon


This chapter contains sections titled:

  • Sources of glycine

  • The interconversion of glycine and serine

  • Glycine oxidase and glyoxylate metabolism

  • One-carbon metabolism

  • Serine biosynthesis

  • Serine catabolism

  • Peptidyl glycine hydroxylase (peptide α-amidase)

  • 5-Aminolevulinic acid and porphyrin synthesis

  • Selenocysteine

  • Further reading