4. Palladium in Heterocyclic Chemistry

  1. John A. Joule1 and
  2. Keith Mills2

Published Online: 6 AUG 2012

DOI: 10.1002/9781118380208.ch4

Heterocyclic Chemistry at a Glance, Second Edition

Heterocyclic Chemistry at a Glance, Second Edition

How to Cite

Joule, J. A. and Mills, K. (2012) Palladium in Heterocyclic Chemistry, in Heterocyclic Chemistry at a Glance, Second Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118380208.ch4

Author Information

  1. 1

    The School of Chemistry, The University of Manchester, UK

  2. 2

    Independent Consultant, UK

Publication History

  1. Published Online: 6 AUG 2012
  2. Published Print: 4 SEP 2012

ISBN Information

Print ISBN: 9780470971222

Online ISBN: 9781118380208



  • palladium in heterocyclic chemistry;
  • palladium catalysis for new C-C and C-heteroatom bonds;
  • palladium-catalysed in ring synthesis of heterocyclic systems;
  • catalyst–ligand and well-established standard catalysts;
  • catalyst–ligand choice, in trial and error;
  • organometallic species and halides cross-coupling;
  • Suzuki–Miyaura reaction, Stannane couplings (Stille reaction);
  • polyhalo-compound selectivity and oxidative addition;
  • Sonogashira reaction, linking alkyne to aromatic ring;
  • carbonylation, and electrophilic palladation reaction


This chapter contains sections titled:

  • Palladium(0)-catalysed (and related) reactions

  • Addition to alkenes: the Heck reaction

  • Carbonylation reactions

  • Cross-coupling reactions between heteroatom nucleophiles and

  • halides – making carbon–heteroatom bonds

  • Triflates as substrates for palladium-catalysed reactions

  • Mechanisms of palladium(0)-catalysed processes

  • Reactions involving electrophilic palladation

  • Copper-catalysed amination

  • Selectivity