6. Diazines

  1. John A. Joule1 and
  2. Keith Mills2

Published Online: 6 AUG 2012

DOI: 10.1002/9781118380208.ch6

Heterocyclic Chemistry at a Glance, Second Edition

Heterocyclic Chemistry at a Glance, Second Edition

How to Cite

Joule, J. A. and Mills, K. (2012) Diazines, in Heterocyclic Chemistry at a Glance, Second Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118380208.ch6

Author Information

  1. 1

    The School of Chemistry, The University of Manchester, UK

  2. 2

    Independent Consultant, UK

Publication History

  1. Published Online: 6 AUG 2012
  2. Published Print: 4 SEP 2012

ISBN Information

Print ISBN: 9780470971222

Online ISBN: 9781118380208

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Keywords:

  • diazines;
  • uridine di/triphosphate, role in glycogen biosynthesis;
  • diazines and alkyl halides, pyridazine, the most reactive;
  • electrophilic substitution at carbon;
  • N-oxides, for electrophilic substitution;
  • halogen nucleophilic displacement, in diazine manipulation;
  • radical substitution, the Minisci reaction;
  • N-deprotonation, N-alkylation and N-arylation;
  • heterocyclic ring reactions, electrophilic additions on nitrogen

Summary

This chapter contains sections titled:

  • Electrophilic addition to nitrogen

  • Electrophilic substitution at carbon

  • Nucleophilic substitution

  • Radical substitution

  • C-Metallated diazines

  • Palladium(0)-catalysed reactions

  • Pericyclic reactions

  • Oxygen substituents

  • N-Oxides

  • Amine substituents

  • Ring synthesis – disconnections

  • Synthesis of pyridazines from 1,4-dicarbonyl compounds

  • Synthesis of pyrimidines from 1,3-dicarbonyl compounds

  • Synthesis of pyrazines from 1,2-dicarbonyl compounds

  • Synthesis of pyrazines from α-amino-carbonyl compounds

  • Benzodiazines

  • Exercises