10. Niacinamide

  1. Patricia K. Farris MD
  1. Diane S. Berson1,
  2. Rosemarie Osborne2,
  3. John E. Oblong2,
  4. Tomohiro Hakozaki2,
  5. Mary B. Johnson2 and
  6. Donald L. Bissett2

Published Online: 22 NOV 2013

DOI: 10.1002/9781118384824.ch10

Cosmeceuticals and Cosmetic Practice

Cosmeceuticals and Cosmetic Practice

How to Cite

Berson, D. S., Osborne, R., Oblong, J. E., Hakozaki, T., Johnson, M. B. and Bissett, D. L. (2013) Niacinamide, in Cosmeceuticals and Cosmetic Practice (ed P. K. Farris), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118384824.ch10

Editor Information

  1. Clinical Associate Professor, Tulane University School of Medicine, New Orleans, LA, USA

Author Information

  1. 1

    Weill Medical College of Cornell University, New York-Presbyterian Hospital, New York, NY, USA

  2. 2

    The Procter & Gamble Company, Cincinnati, OH USA

Publication History

  1. Published Online: 22 NOV 2013
  2. Published Print: 27 DEC 2013

ISBN Information

Print ISBN: 9781118384831

Online ISBN: 9781118384824



  • hyperpigmentation appearance;
  • niacinamide;
  • skin appearance;
  • vitamin B3;
  • wrinkle appearance


This chapter illustrates the myriad dermatological and topical uses of niacinamide in cosmetic formulas, from simple moisturization to providing appearance benefits in patients with dermatological skin disorders such as rosacea via improvement in skin barrier integrity. Niacinamide is vitamin B3, an essential nutrient. In the body, it is converted to the co-factors NADH and NADPH that are involved in many biochemical reactions. Clinical evaluations of topical formulations containing this vitamin have identified a wide range of skin care benefits. Dermatological effects of topical niacinamide have also been observed in human testing, such as improvements in acne and bullous pemphigoid. Vitamin B3 is present in many food sources. Three primary forms of vitamin B3 have been used in topical skin care products: niacinamide, nicotinic acid, and nicotinate esters. The chapter further discusses the skin care benefits observed in vehicle-controlled, randomized, double-blind, and statistically powered human clinical testing.