10. Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction
- Tahira Farooqui and
- Akhlaq A. Farooqui
Published Online: 11 OCT 2013
This edition first published 2013 © 2013 John Wiley & Sons, Inc.
Metabolic Syndrome and Neurological Disorders
How to Cite
Lim, J.-S. and Kwon, H.-M. (2013) Metabolic Syndrome as an Independent Risk Factor of Silent Brain Infarction, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch10
- Published Online: 11 OCT 2013
- Published Print: 15 NOV 2013
Print ISBN: 9781118395271
Online ISBN: 9781118395318
- metabolic syndrome (MetS);
- risk factor;
- silent brain infarction (SBI)
Currently, the evidence that supports the association between metabolic syndrome (MetS) and silent brain infarction (SBI) is scarce. Based on the currently available evidence, MetS increased the risk of SBI both in normal healthy adults and the elderly. Full syndrome itself and each constituent such as elevated blood pressure, impaired fasting glucose, high triglyceride level, abnormal high-density lipoprotein, and increased abdominal circumference all showed correlations with SBI. Furthermore, the number of silent lesions increased when the subjects had more components of syndrome. Increased inflammatory activity, action of free radicals, vascular endothelial damage, reduction of insulin transport, and altered neurotrophic factors might be considered as possible pathophysiologic links between MetS and SBI. This chapter outlines the basic concepts of SBI for its epidemiology, characteristics, and health impacts. In addition, the authors have summarized the current evidences for SBI in subjects with MetS.