16. Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Morihiro Matsuda1 and
  2. Iichiro Shimomura2

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch16

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Matsuda, M. and Shimomura, I. (2013) Oxidative Stress and Obesity: Their Impact on Metabolic Syndrome, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch16

Author Information

  1. 1

    Laboratory of Preventive Medicine, Institute of Clinical Research, National Hospital Organization, Kure Medical Center and Chugoku Cancer Center, Hiroshima, Japan

  2. 2

    Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Osaka, Japan

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318



  • adipocytokines;
  • adipose tissue;
  • insulin resistance;
  • metabolic syndrome;
  • obesity;
  • overnutrition;
  • oxidative stress


This chapter discusses oxidative stress in adipose tissue and its involvement in several features of metabolic syndrome. Adipocytes produce various kinds of biologically active substances, which are conceptualized as adipocytokines/adipokines. In 3T3L1 adipocytes, TNFα and glucocorticoid facilitate reactive oxygen species (ROS) generation, and treatment with an anti-oxidative agent, MnTBAP, or with anti-oxidative enzymes such as superoxide dismutase (SOD) or catalase, can improve insulin resistance. Oxidative stress in the brain is involved in the pathogenesis of obesity-associated hypertension. Reduction of oxidative stress by angiotensin II receptor blockers (ARBs) may provide additional beneficial effects for the cardiovascular system beyond blood pressure, especially among patients with hypertension associated with metabolic syndrome. To date, lifestyle changes, such as improving overnutrition, comprise the most important clinical strategy to reduce oxidative stress and prevent many of the features of metabolic syndrome, as well as the development of cardiovascular diseases.