18. Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome
- Tahira Farooqui and
- Akhlaq A. Farooqui
Published Online: 11 OCT 2013
This edition first published 2013 © 2013 John Wiley & Sons, Inc.
Metabolic Syndrome and Neurological Disorders
How to Cite
Gandhi, H. and Balaraman, R. (2013) Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch18
- Published Online: 11 OCT 2013
- Published Print: 15 NOV 2013
Print ISBN: 9781118395271
Online ISBN: 9781118395318
- insulin resistance;
- metabolic syndrome;
- retinol binding protein-4 (RBP-4);
Several epidemiological studies have shown that metabolic syndrome poses a significant risk to the health of the population. Although the syndrome does not have an impromptu profile, the gradual build-up of the condition may put patients in a grave situation. The bioactive adipocytokines secreted by the adipose tissue play a significant role in governing the pathological development of metabolic syndrome. Adiponectin and other adipocytokines like visfatin and leptin provide a link between the development of obesity and insulin resistance. Resistin and retinol binding protein-4 (RBP-4) have been implicated to play a role in the development of obesity and metabolic syndrome. Some adipocytokines show protective actions whereas others have been found to mediate the disparaging pathophysiological features of insulin resistance, obesity, and metabolic syndrome. Such functions of adipocytokines are dependent on the dynamic modulations governed by several factors like nutrition.