18. Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Hardik Gandhi and
  2. Ramachandran Balaraman

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch18

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Gandhi, H. and Balaraman, R. (2013) Involvement of Adipocytokines in Pathogenesis of Insulin Resistance, Obesity, and Metabolic Syndrome, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch18

Author Information

  1. Pharmacology Lab, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat, India

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

SEARCH

Keywords:

  • adipocytokines;
  • adiponectin;
  • insulin resistance;
  • leptin;
  • metabolic syndrome;
  • obesity;
  • resistin;
  • retinol binding protein-4 (RBP-4);
  • visfatin

Summary

Several epidemiological studies have shown that metabolic syndrome poses a significant risk to the health of the population. Although the syndrome does not have an impromptu profile, the gradual build-up of the condition may put patients in a grave situation. The bioactive adipocytokines secreted by the adipose tissue play a significant role in governing the pathological development of metabolic syndrome. Adiponectin and other adipocytokines like visfatin and leptin provide a link between the development of obesity and insulin resistance. Resistin and retinol binding protein-4 (RBP-4) have been implicated to play a role in the development of obesity and metabolic syndrome. Some adipocytokines show protective actions whereas others have been found to mediate the disparaging pathophysiological features of insulin resistance, obesity, and metabolic syndrome. Such functions of adipocytokines are dependent on the dynamic modulations governed by several factors like nutrition.