19. Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue
- Tahira Farooqui and
- Akhlaq A. Farooqui
Published Online: 11 OCT 2013
This edition first published 2013 © 2013 John Wiley & Sons, Inc.
Metabolic Syndrome and Neurological Disorders
How to Cite
Calabro, P., Golia, E., Maddaloni, V., Limongelli, G., Ziello, B., Fimiani, F., Jane Romano, I., Crisci, M., Russo, M. G., Yeh, E. T.H. and Calabro, R. (2013) Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch19
- Published Online: 11 OCT 2013
- Published Print: 15 NOV 2013
Print ISBN: 9781118395271
Online ISBN: 9781118395318
- adipose tissue;
- vascular disease;
- weight loss
Obesity is an extensively studied risk factor for cardiovascular disease, and recently, several studies have highlighted an active role of visceral fat in determining obesity-related vascular complications. Inflammation and release of aberrant mediators are thought to play major roles in this process. Hyperplasia and hypertrophy of fat cells are associated with phenotypic change of the cellular components of adipose tissue, leading to an altered secretory output. Adicytokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone and biology by acting as circulatory hormones. More than 30 so-called adipocytokines have been identified in recent years, but only some of them have been associated with inflammatory response modulation and vascular disease, such as C reactive protein (CRP), adiponectin, TNF alpha, leptin, and resistin. This chapter reviews novel insights regarding the role of adipocytokines in the pathophysiological continuum between obesity and vascular disease.