19. Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Paolo Calabro,
  2. Enrica Golia,
  3. Valeria Maddaloni,
  4. Giuseppe Limongelli,
  5. Brunella Ziello,
  6. Fabio Fimiani,
  7. Ilaria Jane Romano,
  8. Mario Crisci,
  9. Maria Giovanna Russo,
  10. Edward T.H. Yeh and
  11. Raffaele Calabro

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch19

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Calabro, P., Golia, E., Maddaloni, V., Limongelli, G., Ziello, B., Fimiani, F., Jane Romano, I., Crisci, M., Russo, M. G., Yeh, E. T.H. and Calabro, R. (2013) Obesity, Inflammation, and Vascular Disease: Novel Insight in the Role of Adipose Tissue, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch19

Author Information

  1. Division of Cardiology, Second University of Naples, Naples, Italy

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

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Keywords:

  • adipocytokine;
  • adipose tissue;
  • inflammation;
  • leptin;
  • obesity;
  • vascular disease;
  • weight loss

Summary

Obesity is an extensively studied risk factor for cardiovascular disease, and recently, several studies have highlighted an active role of visceral fat in determining obesity-related vascular complications. Inflammation and release of aberrant mediators are thought to play major roles in this process. Hyperplasia and hypertrophy of fat cells are associated with phenotypic change of the cellular components of adipose tissue, leading to an altered secretory output. Adicytokines secreted by visceral, subcutaneous, and perivascular adipocytes are involved in the regulation of vascular tone and biology by acting as circulatory hormones. More than 30 so-called adipocytokines have been identified in recent years, but only some of them have been associated with inflammatory response modulation and vascular disease, such as C reactive protein (CRP), adiponectin, TNF alpha, leptin, and resistin. This chapter reviews novel insights regarding the role of adipocytokines in the pathophysiological continuum between obesity and vascular disease.