21. Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Lu Cai

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch21

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Cai, L. (2013) Role of Iron in the Pathogenesis of Diabetes and Metabolic Syndrome, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch21

Author Information

  1. Departments of Pediatrics, Radiation Oncology, and Pharmacology and Toxicology, the University of Louisville, Louisville, USA

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

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Keywords:

  • diabetes;
  • diabetic complications;
  • iron chelators;
  • iron deficiency;
  • iron homeostasis;
  • iron overload;
  • metabolic syndrome (MetS);
  • pathogenesis

Summary

Oxidative stress is one of the major causative factors for metabolic syndrome (MetS) and diabetes as well as diabetic complications. Increasing evidence has indicated that iron overload not only increases the risk of insulin resistance and diabetes, but also causes cardiovascular diseases in non-diabetic and diabetic subjects. This chapter first outlines iron homeostasis, biological function, and toxicity, and then summarizes the data regarding the roles of iron in the pathogenesis of diabetes, MetS, and diabetic complications. It reviews the epidemiological studies showing the association among iron deficiency or overload and impaired glucose tolerance, diabetes, and diabetic complications. New insights into understanding the possible mechanisms by which iron deficiency or overload may cause the onset of diabetes and diabetic complications are also discussed. In the last part, the potential use of iron chelators as well as its combination with other components for the therapy of diabetic patients will also be discussed.