22. Contributions of AMP kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases
- Tahira Farooqui and
- Akhlaq A. Farooqui
Published Online: 11 OCT 2013
This edition first published 2013 © 2013 John Wiley & Sons, Inc.
Metabolic Syndrome and Neurological Disorders
How to Cite
Kodiha, M., Mahboubi, H. and Stochaj, U. (2013) Contributions of AMP kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch22
- Published Online: 11 OCT 2013
- Published Print: 15 NOV 2013
Print ISBN: 9781118395271
Online ISBN: 9781118395318
- 5'-AMP activated kinase (AMPK);
- human health;
- neurodegenerative diseases;
5'-AMP activated kinase (AMPK) serves as an energy sensor that is implicated in numerous biological processes. This ser/thr protein kinase provides a focal point for metabolic control in all eukaryotes, where it exerts essential functions in different organs and cell types. Due to its critical function in metabolism, AMPK has been recognized as a key player in many human diseases and disorders. Thus, as a crucial regulator of glucose, lipid, and protein homeostasis, AMPK is now an important therapeutic target for type 2 diabetes, obesity, and cancer. This chapter discusses the specific roles that AMPK plays in different organs and tissues. The chapter places emphasis on those that are particularly relevant to human health. Finally, it focuses on the processes that link AMPK to type 2 diabetes and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease.