22. Contributions of AMP kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Mohamed Kodiha,
  2. Hicham Mahboubi and
  3. Ursula Stochaj

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch22

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Kodiha, M., Mahboubi, H. and Stochaj, U. (2013) Contributions of AMP kinase to the Pathogenesis of Type 2 Diabetes and Neurodegenerative Diseases, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch22

Author Information

  1. Department of Physiology, McGill University, Montreal, Canada

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

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Keywords:

  • 5'-AMP activated kinase (AMPK);
  • cancer;
  • diabetes;
  • human health;
  • neurodegenerative diseases;
  • obesity

Summary

5'-AMP activated kinase (AMPK) serves as an energy sensor that is implicated in numerous biological processes. This ser/thr protein kinase provides a focal point for metabolic control in all eukaryotes, where it exerts essential functions in different organs and cell types. Due to its critical function in metabolism, AMPK has been recognized as a key player in many human diseases and disorders. Thus, as a crucial regulator of glucose, lipid, and protein homeostasis, AMPK is now an important therapeutic target for type 2 diabetes, obesity, and cancer. This chapter discusses the specific roles that AMPK plays in different organs and tissues. The chapter places emphasis on those that are particularly relevant to human health. Finally, it focuses on the processes that link AMPK to type 2 diabetes and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease.