26. Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Harald Mangge and
  2. Gunter Almer

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch26

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Mangge, H. and Almer, G. (2013) Contribution of Inflammation, Adiponectin, and Obesity in Cardiovascular Diseases, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch26

Author Information

  1. Research Unit on Lifestyle and Inflammation-associated Risk Biomarkers, Clinical Institute of Medical and Chemical Laboratory Diagnosis, Graz, Austria

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

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Keywords:

  • adiponectin;
  • atherosclerosis (AS);
  • cardiovascular disease (CVD);
  • inflammation;
  • obesity

Summary

Atherosclerosis (AS) leading to cardiovascular disease (CVD) is the main cause of death in developed countries. The pathophysiologic scenario of vulnerable/culprit atherosclerotic lesions responsible for clinical endpoints like myocardial infarction (MI) or stroke encompasses a cascade of cellular and molecular events that can well be characterized as a chronic immune-mediated inflammation occurring preferentially in cases of the so-called metabolic syndrome (MetS). Adipokines, chemokines, cytokines, and their receptors are critically involved in the initiation and perpetuation of AS, and they play important roles at all levels in the pathogenesis of this disease. Metabolic risk profiles associated with sedentary lifestyle, obesity-especially intra-abdominal fat accumulation, insulin resistance, and dyslipidemia pave the way for a chronic, immune-mediated vascular inflammation around lipid deposits. Besides pro-atherogenic molecules like interleukin-(IL)-6, adipocytes synthesize anti-atherogenic proteins, like adiponectin, that are critically dysregulated in cases of MetS.