32. Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome
- Tahira Farooqui and
- Akhlaq A. Farooqui
Published Online: 11 OCT 2013
This edition first published 2013 © 2013 John Wiley & Sons, Inc.
Metabolic Syndrome and Neurological Disorders
How to Cite
Castanon, N. and Layé, S. (2013) Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch32
- Published Online: 11 OCT 2013
- Published Print: 15 NOV 2013
Print ISBN: 9781118395271
Online ISBN: 9781118395318
- cognitive alterations;
- metabolic syndrome (MetS);
- neuropsychiatric symptoms
This chapter provides a new perspective on the pathophysiological mechanisms contributing to the development of neuropsychiatric symptoms in the context of metabolic syndrome (MetS). The authors propose that alterations in mood and cognition occurring in MetS patients may reflect the neural consequences of some molecular and cellular events that play a pivotal role in the evolution of the disease. The chapter concentrates on the hypothesis that inflammation may contribute to the development of clinical signs of neuropsychiatric symptoms reported in MetS patients. The authors show that the neuroinflammation, particularly in the hippocampus, parallels the severity of MetS symptoms and is associated with development of mood and cognitive alterations. These findings may prove valuable for introducing new pharmacological and/or nutritional strategies to treat neuropsychiatric complications associated with MetS.