32. Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Nathalie Castanon and
  2. Sophie Layé

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch32

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Castanon, N. and Layé, S. (2013) Inflammation-Mediated Cognitive and Emotional Alterations in Experimental Models of Metabolic Syndrome, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch32

Author Information

  1. Laboratory of Nutrition and Integrative Neurobiology, UMR 1286 INRA, University of Bordeaux, Bordeaux, France

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

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Keywords:

  • cognitive alterations;
  • inflammation;
  • metabolic syndrome (MetS);
  • neuropsychiatric symptoms

Summary

This chapter provides a new perspective on the pathophysiological mechanisms contributing to the development of neuropsychiatric symptoms in the context of metabolic syndrome (MetS). The authors propose that alterations in mood and cognition occurring in MetS patients may reflect the neural consequences of some molecular and cellular events that play a pivotal role in the evolution of the disease. The chapter concentrates on the hypothesis that inflammation may contribute to the development of clinical signs of neuropsychiatric symptoms reported in MetS patients. The authors show that the neuroinflammation, particularly in the hippocampus, parallels the severity of MetS symptoms and is associated with development of mood and cognitive alterations. These findings may prove valuable for introducing new pharmacological and/or nutritional strategies to treat neuropsychiatric complications associated with MetS.