4. Insulin–Leptin Signaling in the Brain

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Vicente Barrios1,3,
  2. Emma Burgos-Ramos1 and
  3. Jesús Argente1,3

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch4

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Barrios, V., Burgos-Ramos, E. and Jesús Argente (2013) Insulin–Leptin Signaling in the Brain, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch4

Author Information

  1. 1

    Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa, Madrid, Spain

  2. 3

    Centro de Investigación Biomédica en Red de Fisiopatología Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, E-28009, Madrid, Spain

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318



  • brain;
  • energy homeostasis;
  • insulin resistance;
  • insulin-leptin signaling;
  • metabolic disorders;
  • neurodegenerative diseases


This chapter first reviews the central regulation of food intake and energy balance, and then describes brain insulin-leptin signaling mechanisms and the cross-talk between these hormones. Finally, some situations where metabolic disorders and neurodegenerative diseases associated with disturbances in leptin and/or insulin signaling are illustrated. Leptin and insulin play a key role in the central control of feeding and body weight, with interconnected signaling pathways at various levels. In addition, central resistance to their actions has a primary role in the pathogenesis of obesity and type 2 diabetes. Studies performed in knockout mice for insulin targets show that the impairment of insulin signaling is related to changes in learning and memory.