8. Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated Neurotoxicity

  1. Tahira Farooqui and
  2. Akhlaq A. Farooqui
  1. Mun'delanji C. Vestergaard,
  2. Masamune Morita,
  3. Tsutomu Hamada and
  4. Masahiro Takagi

Published Online: 11 OCT 2013

DOI: 10.1002/9781118395318.ch8

Metabolic Syndrome and Neurological Disorders

Metabolic Syndrome and Neurological Disorders

How to Cite

Vestergaard, M. C., Morita, M., Hamada, T. and Takagi, M. (2013) Lipids, Cholesterol, and Oxidized Cholesterol in Alzheimer Amyloid Beta-Mediated Neurotoxicity, in Metabolic Syndrome and Neurological Disorders (eds T. Farooqui and A. A. Farooqui), John Wiley & Sons Ltd, Chichester, UK. doi: 10.1002/9781118395318.ch8

Author Information

  1. School of Materials Science, Japan Advanced Institute of Science and Technology, Ishikawa, Japan

Publication History

  1. Published Online: 11 OCT 2013
  2. Published Print: 15 NOV 2013

ISBN Information

Print ISBN: 9781118395271

Online ISBN: 9781118395318

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Keywords:

  • Alzheimer disease (AD);
  • amyloid beta interaction;
  • cholesterol oxidation;
  • lipids;
  • model membrane systems;
  • neurotoxicity;
  • oxidized cholesterol

Summary

The use of biomimetic membranes enables a researcher to manipulate a “biological” microvesicle under a controlled environment. This chapter focuses on the use of such membrane systems in understanding (1) the mis-folding of the amyloid beta (Aβ)-peptide; (2) how changes in composition of the membrane affect mis-folding; and (3) how different species of mis-folded Aβ localize in membranes. It discusses the reported role(s) of Aβ peptide, a widely accepted biomarker of Alzheimer disease (AD). The chapter clarifies the role played by membrane lipids, in particular, cholesterol in influencing the interaction between Aβ and the membrane. It demonstrates the use of biomimetic membrane systems, and how these have been explored in enhancing our understanding of the interaction of Aβ with membranes. Finally, the chapter discusses changes in membrane characteristics including fluidity, molecular packing, surface area, and their relationship with membrane morphological changes in the presence of Aβ.