2. Headache due to Systemic Disease

  1. Steven L. Lewis MD, FAAN
  1. Kevin A. Kahn MD1,2,3,4

Published Online: 24 JAN 2013

DOI: 10.1002/9781118414019.ch2

Neurological Disorders due to Systemic Disease

Neurological Disorders due to Systemic Disease

How to Cite

Kahn, K. A. (2013) Headache due to Systemic Disease, in Neurological Disorders due to Systemic Disease (ed S. L. Lewis), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118414019.ch2

Editor Information

  1. Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. 1

    Clinical Care Center, Carolina Headache Institute, Chapel Hill, NC, USA

  2. 2

    Department of Psychiatry, Chapel Hill, NC, USA

  3. 3

    Department of Anesthesiology, UNC School of Medicine, Chapel Hill, NC, USA

  4. 4

    UNC School of Dentistry, Chapel Hill, NC, USA

Publication History

  1. Published Online: 24 JAN 2013
  2. Published Print: 10 FEB 2013

ISBN Information

Print ISBN: 9781444335576

Online ISBN: 9781118414019



  • antiphospholipid antibody syndrome;
  • endocrine;
  • headache;
  • metabolic dysfunction;
  • migraine;
  • organ transplantation;
  • systemic disease


This chapter reviews the impact that systemic disease can have upon the mechanisms that cause head pain. Headache can be caused by direct influence on pericranial and intracranial pain-sensitive structures or initiated by pain modulatory systems within the brain. Systemic disease can influence both of these paradigms to cause a wide variety of headache types. The review covers the following areas: endocrine dysfunction, metabolic disorders, autoimmune dysfunction, organ disease, cancer, infection, transplantation, critical medical illness, vitamins, drugs, and toxins. The analysis of these disciplines includes both review of both the current medical literature and the classification of various headache types as defined by the International Headache Society.