1. Esophageal Squamous Cell Carcinoma
- Janusz Jankowski MB ChB, MSc, MD, PhD, FRCP, FACG, AGAF2,3,4,
- Ernest Hawk MD, MPH5
Published Online: 15 NOV 2012
DOI: 10.1002/9781118423318.ch1
This edition first published 2013 © 2013 John Wiley & Sons Ltd.
Book Title
Handbook of Gastrointestinal Cancer
Additional Information
How to Cite
Tian, J. and Wang, K. K. (2012) Esophageal Squamous Cell Carcinoma, in Handbook of Gastrointestinal Cancer (eds J. Jankowski and E. Hawk), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118423318.ch1
Editor Information
- 2
Sir James Black Professor of Gastrointestinal Biology and Trials, Centre for Digestive Diseases, Barts and Th e London School of Medicine and Dentistry, London, UK
- 3
Consultant Gastroenterologist, University Hospitals of Leicester, Leicester, UK
- 4
James Black Senior Fellow, University of Oxford, Oxford, UK
- 5
Vice President and Division Head, Division of Cancer Prevention & Population Sciences, Boone Pickens Distinguished Chair for Early Prevention of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Publication History
- Published Online: 15 NOV 2012
- Published Print: 12 JUL 2012
ISBN Information
Print ISBN: 9780470656242
Online ISBN: 9781118423318
- Summary
- Chapter
- References
Keywords:
- Esophageal squamous cell carcinoma;
- endoscopic mucosal resection;
- endoscopic submucosal dissection;
- esophagectomy;
- chemoradiotherapy
Summary
Esophageal squamous cell carcinoma is the predominant type of esophageal cancer worldwide, and in the United States, it has disproportionately high incidence and mortality in certain subgroups with cigarette smoking, excessive alcohol drinking, and comorbidities. This is particularly true in minority populations, which highlights health care disparities. Specific agents have been implicated in the pathogenesis of these tumors in select populations as well, such as polycyclic aromatic hydrocarbons generated from cooking. In recent years, many new endoscopic and laboratory technologies have been developed to diagnose this cancer at an early stage, and new staging guidelines have been published. Although there has been a tendency to combine all esophageal carcinomas for treatment studies, there is emerging evidence that these morphologically distinct entities have important differences in their biologies and metastatic potential. Recent studies also shed light on the complex multidisciplinary treatments for squamous cell carcinoma.