1. Esophageal Squamous Cell Carcinoma

  1. Janusz Jankowski MB ChB, MSc, MD, PhD, FRCP, FACG, AGAF2,3,4 and
  2. Ernest Hawk MD, MPH5
  1. Jianmin Tian and
  2. Kenneth K. Wang

Published Online: 15 NOV 2012

DOI: 10.1002/9781118423318.ch1

Handbook of Gastrointestinal Cancer

Handbook of Gastrointestinal Cancer

How to Cite

Tian, J. and Wang, K. K. (2012) Esophageal Squamous Cell Carcinoma, in Handbook of Gastrointestinal Cancer (eds J. Jankowski and E. Hawk), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118423318.ch1

Editor Information

  1. 2

    Sir James Black Professor of Gastrointestinal Biology and Trials, Centre for Digestive Diseases, Barts and Th e London School of Medicine and Dentistry, London, UK

  2. 3

    Consultant Gastroenterologist, University Hospitals of Leicester, Leicester, UK

  3. 4

    James Black Senior Fellow, University of Oxford, Oxford, UK

  4. 5

    Vice President and Division Head, Division of Cancer Prevention & Population Sciences, Boone Pickens Distinguished Chair for Early Prevention of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Author Information

  1. Mayo Clinic, Rochester, MN, USA

Publication History

  1. Published Online: 15 NOV 2012
  2. Published Print: 12 JUL 2012

ISBN Information

Print ISBN: 9780470656242

Online ISBN: 9781118423318



  • Esophageal squamous cell carcinoma;
  • endoscopic mucosal resection;
  • endoscopic submucosal dissection;
  • esophagectomy;
  • chemoradiotherapy


Esophageal squamous cell carcinoma is the predominant type of esophageal cancer worldwide, and in the United States, it has disproportionately high incidence and mortality in certain subgroups with cigarette smoking, excessive alcohol drinking, and comorbidities. This is particularly true in minority populations, which highlights health care disparities. Specific agents have been implicated in the pathogenesis of these tumors in select populations as well, such as polycyclic aromatic hydrocarbons generated from cooking. In recent years, many new endoscopic and laboratory technologies have been developed to diagnose this cancer at an early stage, and new staging guidelines have been published. Although there has been a tendency to combine all esophageal carcinomas for treatment studies, there is emerging evidence that these morphologically distinct entities have important differences in their biologies and metastatic potential. Recent studies also shed light on the complex multidisciplinary treatments for squamous cell carcinoma.