6. Anal Cancer

  1. Janusz Jankowski MB ChB, MSc, MD, PhD, FRCP, FACG, AGAF3,4,5 and
  2. Ernest Hawk MD, MPH6
  1. Jeffrey J. Meyer1,
  2. Christopher G. Willett2 and
  3. Brian G. Czito2

Published Online: 15 NOV 2012

DOI: 10.1002/9781118423318.ch6

Handbook of Gastrointestinal Cancer

Handbook of Gastrointestinal Cancer

How to Cite

Meyer, J. J., Willett, C. G. and Czito, B. G. (2012) Anal Cancer, in Handbook of Gastrointestinal Cancer (eds J. Jankowski and E. Hawk), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118423318.ch6

Editor Information

  1. 3

    Sir James Black Professor of Gastrointestinal Biology and Trials, Centre for Digestive Diseases, Barts and Th e London School of Medicine and Dentistry, London, UK

  2. 4

    Consultant Gastroenterologist, University Hospitals of Leicester, Leicester, UK

  3. 5

    James Black Senior Fellow, University of Oxford, Oxford, UK

  4. 6

    Vice President and Division Head, Division of Cancer Prevention & Population Sciences, Boone Pickens Distinguished Chair for Early Prevention of Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Author Information

  1. 1

    UT-Southwestern Medical Center, Dallas, TX, USA

  2. 2

    Duke University Medical Center, Durham, NC, USA

Publication History

  1. Published Online: 15 NOV 2012
  2. Published Print: 12 JUL 2012

ISBN Information

Print ISBN: 9780470656242

Online ISBN: 9781118423318



  • Anal cancer;
  • radiation;
  • chemotherapy;
  • surgery;
  • human papillomavirus


This chapter provides an overview of the epidemiology, diagnosis, and treatment of the various tumors that arise in the anal canal and surrounding perianal skin. In particular, we focus on the evolution of treatment for squamous cell anal canal cancers, and discuss recent advances in combined modality therapy for this disease. We also highlight potential future developments aimed at improving tumor control rates while minimizing treatment-associated toxicities.