13. AD-Type Neuron Loss in Transgenic Mouse Models

  1. Peter R. Mouton PhD
  1. Kebreten F. Manaye1 and
  2. Peter R. Mouton2

Published Online: 22 NOV 2013

DOI: 10.1002/9781118444177.ch13

Neurostereology: Unbiased Stereology of Neural Systems

Neurostereology: Unbiased Stereology of Neural Systems

How to Cite

Manaye, K. F. and Mouton, P. R. (2014) AD-Type Neuron Loss in Transgenic Mouse Models, in Neurostereology: Unbiased Stereology of Neural Systems (ed P. R. Mouton), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118444177.ch13

Author Information

  1. 1

    Department of Physiology and Biophysics, College of Medicine, Howard University, Washington, DC, USA

  2. 2

    Department of Pathology and Cell Biology, Byrd Alzheimer's Disease Institute, University of South Florida, Tampa, FL, USA

Publication History

  1. Published Online: 22 NOV 2013
  2. Published Print: 17 JAN 2014

ISBN Information

Print ISBN: 9781118444214

Online ISBN: 9781118444177

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Keywords:

  • AD-type neuron loss;
  • Alzheimer's disease (AD);
  • amyloid precursor protein (APP);
  • transgenic mouse

Summary

A major challenge in the field of Alzheimer's disease (AD) research is to identify the mechanisms underlying the distinctive pattern of neuropathology. A common feature in the majority of transgenic murine models of AD is the overexpression of amyloid precursor protein (APP) that undergoes downstream cleavage to mutant Aß peptides, leading to the deposition of AD-type amyloid plaques in neocortical tissue. This chapter presents a study that uses computerized stereology studies to assess whether 3xTg mice show AD-type loss of neurons in pontine locus coeruleus (LC) and CA1 region of the hippocampus. These results are contrasted and compared with the earlier findings of neuron loss in LC and CA1 in dtg APPswe/PS1ΔE9 mice. The findings are then analyzed with respect to the distinct patterns of extracellular and intracellular Aß deposits in 3xTg mice and dtg APPswe/PS1ΔE9 mice.