14. Quantification in Populations of Nonuniformly Distributed Cells in the Human Cerebral Cortex

  1. Peter R. Mouton PhD
  1. William L. Maxwell

Published Online: 22 NOV 2013

DOI: 10.1002/9781118444177.ch14

Neurostereology: Unbiased Stereology of Neural Systems

Neurostereology: Unbiased Stereology of Neural Systems

How to Cite

Maxwell, W. L. (2014) Quantification in Populations of Nonuniformly Distributed Cells in the Human Cerebral Cortex, in Neurostereology: Unbiased Stereology of Neural Systems (ed P. R. Mouton), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118444177.ch14

Author Information

  1. Department of Anatomy, School of Biological Sciences, University of Glasgow, Glasgow, UK

Publication History

  1. Published Online: 22 NOV 2013
  2. Published Print: 17 JAN 2014

ISBN Information

Print ISBN: 9781118444214

Online ISBN: 9781118444177

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Keywords:

  • human cerebral cortex;
  • nonpyramidal cells;
  • nonuniformly distributed cells;
  • Poisson distribution;
  • traumatic brain injury (TBI)

Summary

This chapter presents a study that uses brains of 11 patients with no history of brain damage or disease were investigated using stereological techniques. For glial responses to traumatic brain injury (TBI), data are included from 13 moderately disabled (MoD), 12 severely disabled (SD), and 11 vegetative state (VS) patients. Approval for this study was obtained from The Research Ethics Committee of the Southern General Hospital. Brain pH was not recorded for the material in the present study and a correction factor could not be applied. The study provides novel, statistically valid evidence that the proportion of pyramidal to nonpyramidal cells differed between different cortical layers and between different types of cortex. The present study provides novel information in support of the hypothesis that astrocytes follow a Poisson distribution in cerebral cortex.