3. Age Effects in Substantia Nigra of Asian Indians

  1. Peter R. Mouton PhD
  1. Phalguni Anand Alladi

Published Online: 22 NOV 2013

DOI: 10.1002/9781118444177.ch3

Neurostereology: Unbiased Stereology of Neural Systems

Neurostereology: Unbiased Stereology of Neural Systems

How to Cite

Alladi, P. A. (2014) Age Effects in Substantia Nigra of Asian Indians, in Neurostereology: Unbiased Stereology of Neural Systems (ed P. R. Mouton), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118444177.ch3

Author Information

  1. Department of Neurophysiology, National Institute of Mental Health and Neurosciences, Bangalore, India

Publication History

  1. Published Online: 22 NOV 2013
  2. Published Print: 17 JAN 2014

ISBN Information

Print ISBN: 9781118444214

Online ISBN: 9781118444177

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Keywords:

  • age effects;
  • Asian Indians;
  • glial cell-derived neurotrophic growth factor (GDNF);
  • nigral neurons;
  • substantia nigra;
  • substantia nigra pars compacta (SNpc)

Summary

This chapter presents a study in which the authors analyzed a total of 36 midbrain specimens from Asian Indians, including 35 from fatal traffic accidents and a single fetal midbrain obtained from medical termination of pregnancy at 28 weeks of gestation (28GW), to determine age effects in them. The tissue analyzed in the study included the caudal portion of the substantia nigra pars compacta (SNpc), including sections from the caudal level of the mammillary bodies to the rostral border of the corpus quadrigemini. The study showed preserved expression of both glial cell-derived neurotrophic growth factor (GDNF) receptors, that is, GFRa1 and RET, in human SNpc during aging. It provides evidence that GFRa1 and RET were colocalized on the nigral neurons and hence probably were part of the multireceptor complex comparable to the findings in nonhuman primates.