10. Microemulsions for Drug Solubilization and Delivery

  1. Dennis Douroumis1 and
  2. Alfred Fahr2
  1. X.Q. Wang and
  2. Q. Zhang

Published Online: 4 FEB 2013

DOI: 10.1002/9781118444726.ch10

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

How to Cite

Wang, X.Q. and Zhang, Q. (2013) Microemulsions for Drug Solubilization and Delivery, in Drug Delivery Strategies for Poorly Water-Soluble Drugs (eds D. Douroumis and A. Fahr), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118444726.ch10

Editor Information

  1. 1

    School of Science, University of Greenwich, UK

  2. 2

    Friedrich-Schiller University of Jena, Germany

Publication History

  1. Published Online: 4 FEB 2013
  2. Published Print: 21 JAN 2013

ISBN Information

Print ISBN: 9780470711972

Online ISBN: 9781118444726

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Keywords:

  • microemulsion;
  • phase behaviour;
  • solubility;
  • surfactants;
  • cosurfactants;
  • ternary;
  • pseudoternary;
  • Lymphatic Transport;
  • Intestinal Permeability

Summary

Microemulsions are thermodynamically stable isotropic mixtures made of water, oil, surfactants occasionally in combination with cosurfactant and have been extensively used as drug delivery systems for poorly water – soluble drugs. This chapter provides the theoretical aspects for the formation of microemulsions, phase stability and physicochemical characterization approaches. Particular emphasis is given to formulation components such as oils, surfactants, cosurfactants and lipophilic drugs formulated via micoremulsions. Eventually the chapters provides a detailed discussion of various administration routes of microemulsions and future perspectives are discussed.