13. Dendrimers for Enhanced Drug Solubilization

  1. Dennis Douroumis1 and
  2. Alfred Fahr2
  1. Narendra K. Jain and
  2. Rakesh K. Tekade

Published Online: 4 FEB 2013

DOI: 10.1002/9781118444726.ch13

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

How to Cite

Jain, N. K. and Tekade, R. K. (2013) Dendrimers for Enhanced Drug Solubilization, in Drug Delivery Strategies for Poorly Water-Soluble Drugs (eds D. Douroumis and A. Fahr), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118444726.ch13

Editor Information

  1. 1

    School of Science, University of Greenwich, UK

  2. 2

    Friedrich-Schiller University of Jena, Germany

Publication History

  1. Published Online: 4 FEB 2013
  2. Published Print: 21 JAN 2013

ISBN Information

Print ISBN: 9780470711972

Online ISBN: 9781118444726



  • dendrimer;
  • Host—guest interactions;
  • Dendrimer mediated solubilisation;
  • pH responsive dendrimer;
  • Drug—dendrimer conjugation;
  • PEGylated dendrimer;
  • Dendrimer generations;
  • Dendritic box;
  • Dendrimer biomedical applications;
  • Dendrimer biocompatibility and toxicity


Dendrimers are synthetic, absolutely branched, mono-disperse, unimolecular micellar architectures with nanometeric dimensions. They are compartmentalized structures with hydrophobic interiors as well as hydrophilic exteriors that account for their unimolecular micellar nature. Dendrimers are regarded as an exceptional drug delivery vehicle since they have modifiable terminals that enable modification in numerous ways. These architectures have proved themselves to be a proficient vehicle for an assortment of poorly soluble chemical entities with supplementary aptitude to improve their bioavailability. This chapter specifically focuses on the current state-of-the art in the field of dendrimer-based drug delivery with a spotlight on the application of dendrimers in drug solubilization, a promising and likely rewarding area in pharmaceutical product development.