16. Micro- and Nanosizing of Poorly Soluble Drugs by Grinding Techniques

  1. Dennis Douroumis1 and
  2. Alfred Fahr2
  1. Stefan Scheler

Published Online: 4 FEB 2013

DOI: 10.1002/9781118444726.ch16

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

How to Cite

Scheler, S. (2013) Micro- and Nanosizing of Poorly Soluble Drugs by Grinding Techniques, in Drug Delivery Strategies for Poorly Water-Soluble Drugs (eds D. Douroumis and A. Fahr), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118444726.ch16

Editor Information

  1. 1

    School of Science, University of Greenwich, UK

  2. 2

    Friedrich-Schiller University of Jena, Germany

Publication History

  1. Published Online: 4 FEB 2013
  2. Published Print: 21 JAN 2013

ISBN Information

Print ISBN: 9780470711972

Online ISBN: 9781118444726

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Keywords:

  • milling;
  • wet grinding;
  • micronization;
  • nanomilling;
  • nanoparticles;
  • brittle-ductile transition;
  • stirred media mills;
  • NanoCrystal®;
  • bioavailability.

Summary

This chapter describes the ‘top down' approach of grinding crystalline drug particles into the low micrometer or nanometer range. It covers the physical background, equipment and process engineering as well as the biopharmaceutical aspects. Emphasis will be given to media milling techniques, including Elan's NanoCrystal® wet-milling technology.