4. Solid Lipid Nanoparticles for Drug Delivery

  1. Dennis Douroumis1 and
  2. Alfred Fahr2
  1. Sonja Joseph and
  2. Heike Bunjes

Published Online: 4 FEB 2013

DOI: 10.1002/9781118444726.ch4

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

How to Cite

Joseph, S. and Bunjes, H. (2013) Solid Lipid Nanoparticles for Drug Delivery, in Drug Delivery Strategies for Poorly Water-Soluble Drugs (eds D. Douroumis and A. Fahr), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118444726.ch4

Editor Information

  1. 1

    School of Science, University of Greenwich, UK

  2. 2

    Friedrich-Schiller University of Jena, Germany

Publication History

  1. Published Online: 4 FEB 2013
  2. Published Print: 21 JAN 2013

ISBN Information

Print ISBN: 9780470711972

Online ISBN: 9781118444726

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Keywords:

  • Colloidal lipid carriers;
  • Drug incorporation;
  • Drug release;
  • High pressure homogenization;
  • Melting;
  • Microemulsion;
  • Particle morphology;
  • Scale-up feasibility;
  • Solid-state properties;
  • Supercooling

Summary

The chapter on solid lipid nanoparticles introduces colloidal suspensions of crystalline lipids as carrier systems for poorly water-soluble drugs. It describes and compares the various methods to prepare these carrier systems, in particular, different melt-dispersion and precipitation techniques. After that, the general physico-chemical parameters of the dispersions (such as size, morphology, solid state properties and interactions of the lipid nanoparticles) are discussed and related to the pharmaceutical properties of the corresponding drug delivery systems. The interaction of the particles with lipophilic drugs, especially with regard to drug incorporation and in vitro drug release properties, are also an important focus. Moreover, the compatibility of the nanoparticle dispersions with in vitro biological models is considered. The chapter concludes with a summary of in vivo data on the improvement in oral bioavailability of poorly soluble drugs through the use of solid lipid nanoparticle dispersions and the application of such systems in parenteral drug delivery, with a special focus on pharmacokinetics and biodistribution.