5. Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs

  1. Dennis Douroumis1 and
  2. Alfred Fahr2
  1. Naveed Ahmed,
  2. C.E. Mora-Huertas,
  3. Chiraz Jaafar-Maalej,
  4. Hatem Fessi and
  5. Abdelhamid Elaissari

Published Online: 4 FEB 2013

DOI: 10.1002/9781118444726.ch5

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

How to Cite

Ahmed, N., Mora-Huertas, C.E., Jaafar-Maalej, C., Fessi, H. and Elaissari, A. (2013) Polymeric Drug Delivery Systems for Encapsulating Hydrophobic Drugs, in Drug Delivery Strategies for Poorly Water-Soluble Drugs (eds D. Douroumis and A. Fahr), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118444726.ch5

Editor Information

  1. 1

    School of Science, University of Greenwich, UK

  2. 2

    Friedrich-Schiller University of Jena, Germany

Publication History

  1. Published Online: 4 FEB 2013
  2. Published Print: 21 JAN 2013

ISBN Information

Print ISBN: 9780470711972

Online ISBN: 9781118444726

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Keywords:

  • Encapsulation techniques;
  • Nanoprecipitation;
  • Emulsification-diffusion;
  • Emulsification-coacervation;
  • Layer by layer;
  • Multiple emulsions;
  • Supercritical fluid technology;
  • Encapsulation efficiency;
  • Drug release

Summary

This review is based on drug delivery systems involving hydrophobic drug encapsulation. It explains the different methods of preparation for polymeric nanoparticles containing hydrophobic drugs with biocompatibility profiles of polymers. The mechanism, merits, disadvantages and examples of hydrophobic drugs, already used by nanoprecipitation, various emulsification methods, polymersome, layer-by-layer and supercritical fluid technologies are explained. Characterization of the nanoparticles prepared by these methods is given in a comparative way. It permits the selection of a suitable way to prepare nanoparticles of a specific drug on the basis of polymer choice, taking into consideration advantages, disadvantages and the characterization of prepared nanoparticles. Already published data is the basis of this review.