9. Nanosuspensions with Enhanced Drug Dissolution Rates of Poorly Water-Soluble Drugs

  1. Dennis Douroumis1 and
  2. Alfred Fahr2
  1. Dennis Douroumis

Published Online: 4 FEB 2013

DOI: 10.1002/9781118444726.ch9

Drug Delivery Strategies for Poorly Water-Soluble Drugs

Drug Delivery Strategies for Poorly Water-Soluble Drugs

How to Cite

Douroumis, D. (2013) Nanosuspensions with Enhanced Drug Dissolution Rates of Poorly Water-Soluble Drugs, in Drug Delivery Strategies for Poorly Water-Soluble Drugs (eds D. Douroumis and A. Fahr), John Wiley & Sons Ltd, Oxford, UK. doi: 10.1002/9781118444726.ch9

Editor Information

  1. 1

    School of Science, University of Greenwich, UK

  2. 2

    Friedrich-Schiller University of Jena, Germany

Publication History

  1. Published Online: 4 FEB 2013
  2. Published Print: 21 JAN 2013

ISBN Information

Print ISBN: 9780470711972

Online ISBN: 9781118444726

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Keywords:

  • crystal growth;
  • Nucleation;
  • Antisolvent Precipitation;
  • Solubility Supersaturation;
  • Static Mixers;
  • Nanosuspensions;
  • Microfluidic reactors;
  • Spray—Freezing;
  • Supercritical Fluids

Summary

Antisolvent precipitation is a widely used technique for the manufacture of nanosuspensions of poorly water-soluble drugs. Several approaches such as statix mixers, ultrasonication, microfluidic reactors, spray-–freezing into liquid and supercritical fluids have been employed to engineer nanosuspensions. The antisolvent precipitation approaches lead to the development of stable supersaturated nanosuspensions with the addition of stabilizers through electrostatic or steric stabilization. This chapter includes a review of the commonest platforms employed for the development of nanosuspensions of poorly water-soluble drugs, including their advantages and disadvantages.