10. Neuronal Regulation of Bone Remodeling

  1. Clifford J. Rosen MD
  1. Florent Elefteriou and
  2. Gerard Karsenty

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch10

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Elefteriou, F. and Karsenty, G. (2013) Neuronal Regulation of Bone Remodeling, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch10

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • bone mass;
  • bone remodeling;
  • cocaine and amphetamine-regulated transcript (CART);
  • neuronal regulation;
  • sympathetic nervous system (SNS)

Summary

Bone remodeling, the process whereby bone is constantly renewed during adulthood, is a prototypical homeostatic process. This chapter discusses the mechanisms underlying the central control of bone mass in detail. The nature of the downstream mechanism whereby brainstem and hypothalamic neurons regulate the activity of distant cells, such as osteoblasts and osteoclasts, has been determined through genetic and pharmacological approaches. The importance of cocaine and amphetamine-regulated transcript (CART) in regulating bone remodeling and the hypothalamic nature of this regulation is supported by animal models characterized by low or high hypothalamic Cart expression and significant bone phenotypes. The crucial role of the sympathetic nervous system (SNS) in the regulation of bone remodeling leads to the question of the possible role that the other arm of the autonomic nervous system and the parasympathetic nervous system (PNS) may have in bone remodeling.