116. The Pituitary-Bone Connection

  1. Clifford J. Rosen MD
  1. Mone Zaidi,
  2. Tony Yuen,
  3. Li Sun,
  4. Terry F. Davies,
  5. Alberta Zallone and
  6. Harry C. Blair

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch116

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Zaidi, M., Yuen, T., Sun, L., Davies, T. F., Zallone, A. and Blair, H. C. (2013) The Pituitary-Bone Connection, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch116

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • adrenocorticotrophic hormone (ACTH);
  • bone loss;
  • follicle stimulating hormone (FSH);
  • growth hormone (GH);
  • oxytocin (OT);
  • pituitary hormone;
  • thyroid stimulating hormone (TSH)

Summary

This chapter discusses the interaction of each pituitary hormone with bone and the potential it holds in understanding and treating osteoporosis. The discovery of glycoprotein hormones and their direct regulation of bone help explain some of the inconsistencies of older models that assumed that pituitary signaling was mediated entirely via endocrine organs through steroid-family signals. Important direct responses include actions of growth hormone (GH), thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), adrenocorticotrophic hormone (ACTH), and oxytocin (OT) in bone. It is important, in evaluating these new signaling mechanisms, to consider that the skeletal responses may or may not have similar mechanisms to the responses of the traditional endocrine targets, and that the signals may vary in importance due to secondary endocrine and paracrine control. The discovery of direct skeletal responses of pituitary hormones nevertheless offers a new set of therapeutic opportunities.