118. Glucose Control and Integration by the Skeleton

  1. Clifford J. Rosen MD
  1. Patricia Ducy and
  2. Gerard Karsenty

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch118

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Ducy, P. and Karsenty, G. (2013) Glucose Control and Integration by the Skeleton, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch118

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • bone mass accrual;
  • energy homeostasis;
  • glucose metabolism;
  • insulin;
  • osteocalcin

Summary

The cross-talk between the regulation of bone mass accrual and energy metabolism has two major tenets. The first one is represented by the various influences exerted by multiple organs involved in the control of energy intake and metabolism on bone mass accrual. The second tenet arose from a question raised by the existence of this broad, complex, and multifaceted regulation of bone mass by energy metabolism: could bone, as an endocrine organ, exert a feedback regulation on some aspects of energy metabolism? It turned out that this is indeed the case, and this chapter reviews the main aspects of this recently discovered regulation. Osteocalcin regulates glucose and energy homeostasis by acting on beta cell proliferation, insulin production, insulin sensitivity, and energy expenditure. In the authors' view, a most important point is that the role of osteocalcin as a sole marker of bone formation needs to be reevaluated.