120. Neuropsychiatric Disorders and the Skeleton

  1. Clifford J. Rosen MD
  1. Itai Bab and
  2. Raz Yirmiya

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch120

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Bab, I. and Yirmiya, R. (2013) Neuropsychiatric Disorders and the Skeleton, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch120

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • Alzheimer's disease;
  • anorexia nervosa (AN);
  • major depressive disorder (MDD);
  • neuropsychiatrie disorders;
  • schizophrenia;
  • skeleton;
  • traumatic brain injury (TBI)

Summary

It is now well established that some neuropsychiatric diseases, mainly major depressive disorder (MDD), anorexia nervosa (AN), and traumatic brain injury (TBI) are associated with changes in bone mass. Initial indications suggest that schizophrenia and Alzheimer's disease (AD) are accompanied by changes in bone density. A number of first-line agents used in the treatment of neuropsychiatric disorders are associated with low BMD and increased fracture risk, potentially amplifying the negative impact of these disorders on the skeleton. The most urgent unresolved clinical issue is the conflict between the beneficial effects of psychiatric medications, particularly in mood disorders and schizophrenia, and the deleterious effects of the very same medications on the skeleton.