123. Hematopoiesis and Bone

  1. Clifford J. Rosen MD
  1. Benjamin J. Frisch and
  2. Laura M. Calvi

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch123

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Frisch, B. J. and Calvi, L. M. (2013) Hematopoiesis and Bone, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch123

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • B lymphopoiesis;
  • bone;
  • hematopoietic stem cell (HSC);
  • skeletal signals

Summary

This chapter reviews the principal cell types and skeletal signals that have been implicated as regulatory cellular components of the hematopoietic stem cell (HSC) niche. These components not only illustrate the extraordinary complexity of skeletal tissue, but also provides critical clues to novel therapeutic targets for HSC expansion in conditions of myeloablative injury. In addition to HSCs, there is emerging evidence that B lymphopoiesis is regulated by microenvironmental factors in the bone marrow. An area of current interest is the role of the benign niche in hematopoietic malignancies. The importance of the skeletal microenvironment in hematopoietic regulation is beginning to be elucidated and holds great promise for translational therapies aimed at hematopoietic recovery and treatment of hematopoietic malignancies as well as metastatic disease. The importance of the skeletal microenvironment in hematopoietic regulation is beginning to be elucidated and holds great promise for translational therapies aimed at hematopoietic recovery and treatment.