14. Circulating Osteogenic Cells

  1. Clifford J. Rosen MD
  1. Robert J. Pignolo and
  2. Moustapha Kassem

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch14

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Pignolo, R. J. and Kassem, M. (2013) Circulating Osteogenic Cells, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch14

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • bone marrow transplantation experiments;
  • circulating osteogenic precursor (COP) cells;
  • ectopic bone formation experiments;
  • marrow stromal stem cells (MSCs) mobilization;
  • parabiosis experiments

Summary

This chapter summarizes biological characteristics and possible roles of circulating osteogenic precursor (COP) cells that have been studied using a variety of experimental approaches. The experimental approaches include parabiosis experiments, bone marrow transplantation experiments, and ectopic bone formation experiments. Several key concepts appear to be generally true regarding the physiological functions of COP cells. The first is that the bone-forming function of COP cells may not be their primary role but is an adaptive response in conditions of injury, repair, or abnormal cytokine signaling. Second, COP cell homing may be mediated by the CXCR4/SDF-1 axis that is shared by multiple processes requiring the migration of stem cells. Finally, the burgeoning area of COP cell biology holds promise for development of gene and cell therapy protocols to enhance bone formation as well as diagnostic tests based on COP cell levels as a biomarker for disease states.