2. Signal Transduction Cascades Controlling Osteoblast Differentiation

  1. Clifford J. Rosen MD
  1. David J.J. de Gorter and
  2. Peter ten Dijke

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch2

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

de Gorter, D. J.J. and ten Dijke, P. (2013) Signal Transduction Cascades Controlling Osteoblast Differentiation, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch2

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • mesenchymal stem cells (MSCs);
  • osteoblast differentiation;
  • signal transduction cascades

Summary

Mesenchymal stem cells (MSCs) are pluripotent cells located in bone marrow, muscles, and fat that can differentiate into a variety of tissues, including bone, cartilage, muscle and fat. Differentiation toward these lineages is controlled by a multitude of cytokines, which regulate the expression of cell-lineage specific sets of transcription factors. Among the cytokines involved in osteoblast differentiation are the Hedgehogs, BMPs, TGF-ß, PTH, and WNTs. This chapter discusses signal transduction cascades initiated by these cytokines and their effect on osteoblast differentiation. The combined action of the signal transduction pathways induced by bone-promoting cytokines determines the commitment of MSCs toward the osteoblast lineage and the efficiency of bone formation.