26. Parathyroid Hormone

  1. Clifford J. Rosen MD
  1. Robert A. Nissenson and
  2. Harald Jüppner

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch26

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Nissenson, R. A. and Jüppner, H. (2013) Parathyroid Hormone, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch26

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • (1,25) vitamin D;
  • fibroblast growth factor 23 (FGF23);
  • parathyroid hormone (PTH);
  • phosphate excretion

Summary

Chief cells in the parathyroid gland secrete parathyroid hormone (PTH) in response to very small decrements in blood ionized calcium in order to maintain the normocalcemic state. PTH accomplishes this task by promoting bone resorption and releasing calcium from the skeletal reservoir; by reducing urinary calcium losses and increasing phosphate excretion; and by enhancing intestinal calcium absorption, indirectly through the renal production of the active vitamin D metabolite 1,25(OH)2 vitamin D. The interplay between serum calcium, PTH, fibroblast growth factor 23 (FGF23), 1,25(OH)2 vitamin D, and phosphate permit blood ionized calcium levels to be maintained within very narrow limits over a wide range of dietary calcium intake. The chapter summarizes our current understanding of the biology of PTH secretion and action.