27. Parathyroid Hormone-Related Protein

  1. Clifford J. Rosen MD
  1. John J. Wysolmerski

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch27

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Wysolmerski, J. J. (2013) Parathyroid Hormone-Related Protein, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch27

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • humoral hypercalcemia of malignancy (HHM);
  • parathyroid hormone-related protein (PTHrP);
  • PTHrP receptor (PTHR1)

Summary

Parathyroid hormone-related protein (PTHrP) and PTH are related molecules that can both stimulate the same Type I PTH/PTHrP receptor (PTHR1). In patients with humoral hypercalcemia of malignancy (HHM), PTHrP does reach the circulation and mimics the systemic actions of PTH. This chapter reviews the normal physiology of PTHrP. The common use of PTHR1 allows PTHrP to act as a hormone mimicking the actions of PTH during reproduction, a function preserved from fish to mammals. Although the conservation of these relationships through evolution allows PTHrP to cause hypercalcemia when it is secreted into the circulation by tumors, it is understood that PTHrP is generally a locally produced and locally acting growth factor that participates in normal development and physiology at many diverse sites. The power of mouse genetics has provided insight into the functions of PTHrP. However, much still remains to be learned of its normal biology.