28. Ca2+-Sensing Receptor

  1. Clifford J. Rosen MD
  1. Edward M. Brown

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch28

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Brown, E. M. (2013) Ca2+-Sensing Receptor, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch28

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • biogenesis;
  • Ca2+o-sensing receptor (CaSR);
  • G-protein coupled receptor (GPCR);
  • homeostasis;
  • tissues

Summary

This chapter describes the properties and functions of the Ca2+o-sensing receptor (CaSR), a G-protein coupled receptor (GPCR) that plays a central role in Ca2+o homeostasis by virtue of its capacity to sense extracellular ionized calcium Ca2+o. The CaSR was originally cloned from bovine parathyroid gland and then from several tissues of a variety of other species, including humans. The chapter describes the CaSR gene properties, biogenesis and structure of the CaSR. It explains the binding and activation of CaSR-mediated signaling. In addition to the roles that it plays in tissues participating in Ca2+o homeostasis, the CaSR is expressed in and modulates the functions of numerous other cells uninvolved in mineral ion homeostasis.