29. Vitamin D: Production, Metabolism, Mechanism of Action, and Clinical Requirements

  1. Clifford J. Rosen MD
  1. Daniel Bikle,
  2. John S. Adams and
  3. Sylvia Christakos

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch29

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Bikle, D., S. Adams, J. and Christakos, S. (2013) Vitamin D: Production, Metabolism, Mechanism of Action, and Clinical Requirements, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch29

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • classical target tissues;
  • clinical requirements;
  • keratinocyte function;
  • metabolism;
  • metabolites;
  • nonclassical target tissues;
  • nutritional considerations;
  • vitamin D

Summary

This chapter talks about vitamin D production, metabolism, mechanism of action, and clinical requirements. It discusses transport of vitamin D in the blood. The chapter focuses on internalization of vitamin D metabolites. It describes the regulation of calcium and phosphate metabolism. The chapter discusses classical target tissues of bone, intestine and kidney, and nonclassical target tissues of parathyroid glands and pancreas. It explains the immunobiology of vitamin D, and keratinocyte function in epidermis and hair follicles. Finally, the chapter deals with nutritional considerations and vitamin D treatment strategies.