3. Osteoclast Biology and Bone Resorption

  1. Clifford J. Rosen MD
  1. F. Patrick Ross

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch3

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Ross, F. P. (2013) Osteoclast Biology and Bone Resorption, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch3

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • bone marrow;
  • bone resorption;
  • GTPases;
  • integrin signaling;
  • intracellular signaling pathways;
  • osteoclasts

Summary

Pathological bone loss, regardless of etiology, invariably represents an increase in the rate at which the skeleton is degraded by osteoclasts relative to its formation by osteoblasts. Thus, the prevention of conditions such as osteoporosis requires an understanding of the molecular mechanisms of bone resorption. Macrophage-colony stimulating factor (M-CSF) contributes to the proliferation, survival, and differentiation of osteoclast precursors, as well as the survival and cytoskeletal rearrangement required for efficient bone resorption. This chapter discusses intracellular signaling pathways of osteoclasts. Three major protein classes are involved: adaptors, kinases, and transcription factors, with one significant exception, RANKL-induced release of Ca++, a pathway that activates the calmodulin-dependent phosphatase calcineurin. The chapter summarizes the modulatory effects of kinases and transcription factors, which together regulate receptor-driven proliferation and/or survival of precursors.