36. Bone Biopsy and Histomorphometry in Clinical Practice

  1. Clifford J. Rosen MD
  1. Robert R. Recker

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch36

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Recker, R. R. (2013) Bone Biopsy and Histomorphometry in Clinical Practice, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch36

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • bone biopsy;
  • histomorphometric variables;
  • metabolic bone diseases;
  • transilial biopsy specimens

Summary

This chapter reviews the underlying organization and function of bone cells and identifies a set of basic structural and kinetic histomorphometric variables. Bone biopsy specimens for histomorphometric examination are ordinarily obtained at the transilial site and shipped to specialized laboratories for processing and microscopic analysis. The chapter outlines an approach to interpretation of findings, with examples from a range of metabolic bone diseases. It describes techniques for obtaining, processing, and analyzing transilial biopsy specimens. The chapter discusses clinical situations in which bone histomorphometry can be useful, and relates histomorphometric measures to data from other methods for assessing bone properties and bone physiology.