41. Overview of Pathogenesis

  1. Clifford J. Rosen MD
  1. Ian R. Reid

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch41

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Reid, I. R. (2013) Overview of Pathogenesis, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch41

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

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Keywords:

  • bone mass;
  • osteoporosis;
  • skeletal strength

Summary

The pathogenesis of osteoporosis is as diverse as the influences that determine the strength of the skeleton and the trauma to which it is subjected. This chapter focuses on determinants of skeletal strength. Throughout life, bone mass is influenced by intercurrent illnesses, body weight, lifestyle factors, and some medications, particularly glucocorticoids. In recent years there has been an increasing focus on bone quality, as well as bone quantity. The components of bone quality are continuing to be defined, but include the material properties of both the proteinaceous matrix and the mineral phase of bone, as well as bone architecture. In pathological situations (e.g., Paget's disease) high turnover can result in disruption of the normal lamellar pattern of collagen fibril assembly, leading to the deposition of woven bone.