6. The Composition of Bone

  1. Clifford J. Rosen MD
  1. Adele L. Boskey and
  2. Pamela Gehron Robey

Published Online: 19 JUL 2013

DOI: 10.1002/9781118453926.ch6

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition

How to Cite

Boskey, A. L. and Robey, P. G. (2013) The Composition of Bone, in Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, Eighth Edition (ed C. J. Rosen), John Wiley & Sons, Inc., Ames, USA. doi: 10.1002/9781118453926.ch6

Publication History

  1. Published Online: 19 JUL 2013

ISBN Information

Print ISBN: 9781118453889

Online ISBN: 9781118453926

SEARCH

Keywords:

  • bone composition;
  • extracellular matrix (ECM);
  • noncollagenous proteins (NCPs)

Summary

This chapter focuses on the extracellular matrix (ECM), which is synthesized primarily by osteo-blasts but also contains proteins adsorbed from the circulation. The preponderance of bone is ECM. The chapter summarizes the composition of bone and the salient features of the classes of bone matrix proteins. It lists specific details for the individual ECM components. Bone is a composite material whose extracellular matrix consists of mineral, collagen, water, noncollagenous proteins (NCPs), and lipids in decreasing proportion (depending on age, species, and site). These components have both mechanical and metabolic functions. Each of the components in the organic matrix of bone influences the mechanism of mineral deposition. Some promote mineralization; some inhibit the formation and/ or growth of mineral crystals; and some are multifunctional, promoting in some cases and inhibiting in others.